Gene name:
Ngfr (Tnfrsf16) ;
Protein name:
Tumor necrosis factor receptor superfamily member 16 ;
Alternative:
Low affinity neurotrophin receptor p75NTR ;Gp80-LNGFR ;p75 ICD ;Low-affinity nerve growth factor receptor (NGF receptor) ;
CD:
CD271 ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1 (By similarity). Interacts with BEX1. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts with LINGO1.
Function:
Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MRRAGAACSA | MDRLRLLLLL | ILGVSSGGAK | ETCSTGLYTH | SGECCKACNL |
100:
GEGVAQPCGA | NQTVCEPCLD | NVTFSDVVSA | TEPCKPCTEC | LGLQSMSAPC |
150:
VEADDAVCRC | AYGYYQDEET | GHCEACSVCE | VGSGLVFSCQ | DKQNTVCEEC |
200:
PEGTYSDEAN | HVDPCLPCTV | CEDTERQLRE | CTPWADAECE | EIPGRWIPRS |
250:
TPPEGSDSTA | PSTQEPEVPP | EQDLVPSTVA | DMVTTVMGSS | QPVVTRGTTD |
300:
NLIPVYCSIL | AAVVVGLVAY | IAFKRWNSCK | QNKQGANSRP | VNQTPPPEGE |
350:
KLHSDSGISV | DSQSLHDQQT | HTQTASGQAL | KGDGNLYSSL | PLTKREEVEK |
400:
LLNGDTWRHL | AGELGYQPEH | IDSFTHEACP | VRALLASWGA | QDSATLDALL |
425:
AALRRIQRAD | IVESLCSEST | ATSPV
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Chicken
Mouse
Human
ELISA Kit for Rat Tumor necrosis factor receptor superfamily member 16
ELISA Kit for Rat Tumor necrosis factor receptor superfamily member 16
ELISA Kit for Rat Tumor necrosis factor receptor superfamily member 16
ELISA Kit for Rat Tumor necrosis factor receptor superfamily member 16
CLIA Kit for Rat Tumor necrosis factor receptor superfamily member 16
CLIA Kit for Rat Tumor necrosis factor receptor superfamily member 16
CLIA Kit for Rat Tumor necrosis factor receptor superfamily member 16
CLIA Kit for Rat Tumor necrosis factor receptor superfamily member 16
Polyclonal Antibody for Rat Tumor necrosis factor receptor superfamily member 16
Polyclonal Antibody for Rat Tumor necrosis factor receptor superfamily member 16
Polyclonal Antibody for Rat Tumor necrosis factor receptor superfamily member 16
Polyclonal Antibody for Rat Tumor necrosis factor receptor superfamily member 16
Monoclonal Antibody for Rat Tumor necrosis factor receptor superfamily member 16
Monoclonal Antibody for Rat Tumor necrosis factor receptor superfamily member 16
Monoclonal Antibody for Rat Tumor necrosis factor receptor superfamily member 16
Monoclonal Antibody for Rat Tumor necrosis factor receptor superfamily member 16
Protein for Rat Tumor necrosis factor receptor superfamily member 16
Protein for Rat Tumor necrosis factor receptor superfamily member 16
Protein for Rat Tumor necrosis factor receptor superfamily member 16
Protein for Rat Tumor necrosis factor receptor superfamily member 16
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22
tissue :
Liver .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH NTRK2
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN APOPTOSIS;INTERACTION WITH MAGED1
strain :
Sprague-Dawley .
tissue :
Neural crest .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH KIDINS220
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH NRADD
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH NTRK1 AND KIDINS220;DOMAIN
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH BEX1
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 334-418